Oxycodone / Naltrexone Extended Release

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Unit20
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Hi Everyone

I am new to the site and have been taking pain meds for a little while now. I have made some contacts and found a study that I was very lucky to get in.

The Med I am on currently I will list below, It is a 12 month trial for safety.

Alpharma - (King Pharm) Sponsor

Oxycodone / Naltrexone Hydrochloride- Extended Release / (Similar to EMBEDA)

"When taken properly the Oxy is released in the body and the naltrexone is unused"

I currently take a 20mg AM dose and a 30mg PM dose.

I would not normally take the time and write on this site but after all the good information I have received I thought I would share.

In my opinion the medicine is working very well and the duration is lasting the full 12 hours.

I have just started the trial in Feb and will let you know how it is going later down the road as well.

If anyone has any questions please feel free to ask, As I said I think this Oxy is just as effective or more than the old Oxycontin (OC).

 

Bill

celticgreenman
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King Pharmaceuticals

Unit20,

That's interesting.  King Pharmaceuticals has several medicines in various stages of FDA approval for moderate to severe pain, that have methods of preventing abuse built in.  The ones most commonly known are Remoxy (long acting oxycodone in a high viscous gelatin, like the new OxyContin OP), Embeda (long acting Morphine pellets surrounded by naltrexone), and Acurox (immediate release oxycodone with Niacin).

Thanks for the information.

cgm

 

Cartier.PA-C
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Whew...Niacin has all kinds

Whew...Niacin has all kinds of nasty side effects.  Listen to those stupid commercials with "brothers and sisters" on t.v.- Flushing is the main thing people have trouble with.  It's crazy to see it in people, faces are blood red.  

I wish the OP best of luck. and one question.  Is this a double blind trial with placebo?  How do you know you're getting the trial drug?  Certainly no doubt you're getting real oxycodone but how do you know that its not a pure Oxycodone med and not the one they study?  Read my share but I've never been around a clinical trial and think its pretty interesting.

jordandog
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I was in a trial

I was in a clinical trial ~15 years ago. It was, in fact, a double blind and I did NOT know until 6 months after it was done that I had received the actual drug and NOT a placebo. I am not trying to cause any issue here, but I signed a non-disclosure agreement (and a ton of other papers for Clinical trial Compliance regs) and was forbidden from talking about what the drug was, who made it, my experiences during the trial - basically anything about it. Only those who were on a need to know basis had any kind of info whatsoever.

I was very surprised to see this post up with all it included. Perhaps the OP is under different guidelines, but what I went through was pretty standard for a clinical trial. After all, a pharmaceutical company that is looking to market a new product does not want it's info out there for other companies and they also don't want a patient saying what they are trying "is &*&?" as far as the medication's efficacy or possible side effects. That is just a couple reasons for non-disclosure. As I said, the post 'surprised' me.

celticgreenman
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New Meds

Cartier.PA-C,

Acurox (IR oxycodone/Niacin) is already at the level of the FDA in trials by King Pharmaceuticals.  The Original Poster was speaking of a new, unnamed medicine that is ER oxycodone with naltrexone.  If approved, it would be the only ER oxycodone, as Purdue still holds the patent for OxyContin, and has won the lawsuits against the generics.  King may just not market it until April 2013, when it is believed that Purdue will lose their patent.

Also, the drug trial may be to see if the naltrexone is going to be a factor in this medication.  As oxycodone is a well known drug and its effects are well known, they may just be doing human trials of the delivery system.  Thus, a double blinded study is not needed.  Just a study to see if the naltrexone produces any effects or interfers with the oxycodone.  Just a thought.

cgm

 

SoloCPhT
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Cartier, because of Niacins

Cartier, because of Niacins nasty sides is why it makes a great abuse deterant. If every abuser knows ahead of time that if they intentionally misuse via unconvennon oral methods or over use there oxy orally that they have to deal with profuse sweating, hells fire under there skin, skin tingling, hairs standing on end, redness of the face, etc. etc. they are less likely to do it, lol. I had a buddy one time try and use niacin to clean his system before a drug test for MJ under the idea that since its stored in fat cells and niacin warms your body that it would burn it out of the fat cells. Ha, he failed the drug test and went through ???$*' s fire for no reason.

Unit20
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Yes

Celtic,

Its a 12 month safety study of oxy / naltexone ER Caps.

Your Exactly right it has the little pellets there is a coating of oxy then a thick center that surrounds the naltrexone.

I thought I would post because I did not have to sign anything saying that I could not talk about it.

I thought that people should know because its working very well for me .

It obviously wont be out anytime soon as I said I just started it Last month and will be going till next year(as long as everything is ok).

 

 

 

antisocialDrugseeker
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butrans patches

hi,  im new so i ll make it quick.  has anyone's doc tried them on butrans patches, which you stick on your skin and they release morphine at the correct level hourly for 7 days apparently.

i would be very interested and grateful for your thoughts

keep well

all the best

celticgreenman
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BuTrans Patches

antisocial,

If you have a new question, you should really start a new thread.  Often new questions at the end of another thread get lost.  But, anyways.

BuTrans patches' active ingredient is buprenorphine, not morphine.  They are not used in the States, as buprenorphine is only allowed for the treatment of opioid dependence, not pain management.  There are morphine patches out there, but BuTrans is not one of them.  There was a posting on BuTrans just a few days ago, but I can't seem to find it right now.  Maybe one of the other regular members can remember where it was posted.

cgm

 

Cartier.PA-C
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Yeah I'm with you Solo.  I

Yeah I'm with you Solo.  I see where it would deter someone from taking too much. I picture a guy with a blood red face sitting in the ER waiting room. haha

moonshine
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Unit,Thank you for the

Unit,

Thank you for the information. It's very interesting. It's amazing how many new medications are in trial. I'm always interested in reading about this stuff.

 

Moonshine