New Generic Buprenorphine (Subutex) - NOT TEVA!

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norcalquit
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Midlothian labs is apparently making a foray into the market...

2mg and 8mg tablets.

http://midlothianlabs.com/products.cfm?type=buprenorphine

Ivy
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Is that strange? I

Is that strange? I mean, considering their other products are all Anti-fungal and prescription vitamins......or is this a natural progression?

norcalquit
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I'm actually surprised more

I'm actually surprised more generics aren't available; buprenorphine has been off-label for quite a while.  I think doctors are more reluctant to write for it due to generic availability and no more goodies from Re(a)ckitt-Benckiser.  Obviously they aren't considering it for analgesic use, as that part of the site is "under construction".

I used to take Subutex for back pain, and I had to keep the "Here to Help" people at bay and had to have my doctor explain to them and my pharmacist I really did take it for back pain - off label use.

NullB.X
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S-Tex

Hey - What does it Subutex taste like? Strong as Suboxone or Suboxone Film? Ive heard its like taking a tylenol...

Anyways - If worse comes to worse [**Knocks On Wood**] and I am removed from my father's insurance and cannot get Suboxone anymore, I'm switching to Subutex which my doctor does not have a problem with.

norcalquit
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Subutex (buprenorphne) is

Subutex (buprenorphne) is kind of bitter, but it dissolves fast.  I've only tried the brand (Reckitt-Benckiser), and the Roxane brand, and I think the Roxane brand tastes the same but dissolves faster - the effects are the same.  I've always wondered why they never flavored the buprenorphine-only tablets, or why Reckitt hasn't offered buprenorphine-only film.  They REALLY want you to take the Suboxone for fear you will *misuse* the buprenorphine-only Subutex.  With patches also becoming available, it will be interesting to see how it all plays out.

When I was taking Subutex for lower-back pain, it was great because it lasted a very long time and I found I could even skip weekend doses after a few months.  It's a well-know analgesic in Europe (Temegesic 0.3mg SL tablets), but it isn't indicated for pain in the US.  I had to go to a psychiatrist to get mine prescribed; the PM doctor wouldn't consider it..."It doesn't do anything for pain", she said.  Funny, because it's been used that way for awhile in European countries with studies to back it up.  A cherry-flavored buprenorphine film would be ideal.

Unfortunately, due to some botched surgeries and other medical issues I really don't have time to discuss, I'm back to taking MS-Contin 100mg twice daily with oxycodone 30mg three times a day (really prn; I rarely use all 90 but I'm not telling my doctor that).  It took about 3 days before I could feel the morphine and oxycodone working again after my last dose of Subutex.  All in all I think buprenorphine is good because of a very long half-life and is a great medecine for moderate to somewhat severe pain.

celticgreenman
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Suboxone

Buprenorphine is a partial opioid agonist, used in detox of opioid dependent persons.  It is an opioid, thus it has pain relieving properties, but not as much as the full opioid agonists (codeine, morphine, oxycodone, etc).  To visualize this easier think of the opioid receptors as cups.  Full agonists fill the cup, partial agonists only fill the cup half way and in doing so also block any other opioid from using that receptor.  Thus if buprenorphine is injested it will attach to all the receptors, but only give half a dose of neurotransmitter (half the pain relief).

Suboxone is lemon-lime flavored, don't know why they made it orange colored.  I have a question on the absorption of buprenorphine sublinguilly.  How much gets absorbed through the mucus membrane and how much is dissolved in the saliva and gets swallowed?  I cannot find this information anywhere.

cgm

 

norcalquit
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You can look it up, but off

You can look it up, but off the top of my head I think sublingual administration of buprenorphine has a BA of around 8 or 9 percent.  That's why even the 2mg tablets are considered "high-dose", because European Temgesic SL tablets are only 0.2mg, and Buprenex Injectable doses are only 0.3mg.

It took me about a month to learn the art of efficient SL administration.  Sometimes it would take half an hour to get the most out of the tablet, but I could tell a huge difference if I put the tabs in my mouth, under my tongue and keeping my mouth as dry as possible, I learned how to wiggle my tongue just enough to help breakdown the cornstarch fller and get a larger surface area under the tongue, helping to aid absorption.

A lot of people don't have patience like I do, so their pills are dissolved in about two minutes, with most of the buprenorphine going to their stomach to be destroyed.  That's why I think the film is a good idea; quicker breakdown time and better SL absorption.  If done correctly, you shouldn't even be able to taste the Subutex tablets.  Absorption median is about 8 to 9% SL, but I'm pretty sure I was able to push it up to at least 25% by using my dry mouth, water dropper method.  Don't know how Suboxone tastes, but if you're doing the SL dose correctly (or at least to try to get the most out of it), you should barely taste anything if it's done using the method I used.  PM for details; the biggest thing is not to swallow and make sure your mouth is moist, but not "wet"; you want to keep those pills under the tongue as long as possible for best effect.

J.C.
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Subutex

Been taking Buprenorphine since 2005, and taking generic Subutex for about two years, and it works great! Started getting Subutex in Chicago in 2009 and went to a pharmacy and they asked me "Generic or brand"?, and I was stunned. I got 56 every two weeks at the time and I bought them for $2.83 a pill at a Target pharmacy. But now living in northeast Ohio it was hard to find a doctor who would prescribe it, alot of places had no Subutex prescribing policies. Anyway, I'm seeing this doctor who's in his 80's and has no problem giving them to me. Between his fee $200 and the meds, 70 pills for $210 (3 bucks each) is half as much as I was paying for the films and I was getting them for $7 a film and that's cheap around here, so I'm grateful for the generic Subutex. If you have no insurance and have to pay cash and got a doctor that's willing to give you Subutex, do it! Thet work just the same as the Suboxone tablets, for way less, def worth it!!

 

J.C.
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Absorbtion

Absorbtion of the Bupe tablets is 35 to 40%. I know the films absorbtion is somewhat higher.

norcalquit
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The prices on generic bupe

The prices on generic bupe are going down...last time my roommate filled them (90 x 2mgs monthly - 6mgs per day), the price had dropped from about $260 to $150 this month on the Roxane brand.  This was at a CVS, and appparently they have both the Barr (Teva) brand and the Roxane.