Levorphanol ER

17 replies [Last post]
Sir Ebril
User offline. Last seen 4 years 1 week ago. Offline
Member
Joined: Jan 29 2011
Posts: 26

TheraQuest-

Levorphanol Extended Release (TQ-1020) is a proprietary once-a-day extended release dosage form of the opioid analgesic levorphanol in an abuse deterrent drug delivery system (Levorphanol ER). It has activity at both opioid and non-opioid receptors, thus providing unique pharmacologic advantages over currently marketed strong opioids. Levorphanol is significantly more potent than morphine at the mu, delta and kappa opioid receptor.

Unlike OxyContin, Opana ER, Embeda and Exalgo, Levorphanol's norepinephrine and serotonin reuptake inhibition is comparable to tapentadol (Nucynta) and tramadol (Ultram ER). Consequently, Levorphanol ER targets both opioid modulated ascending pathways and norepinephrine modulated descending pathways of pain in one centrally acting analgesic. Levorphanol also exerts NMDA antagonism which may partly explain its efficacy in neuropathic pain and its ability to reverse tolerance to morphine.

Levorphanol ER is being developed for chronic moderate to severe pain. It will compete in the same opioid market segment as OxyContin, Opana ER, Embeda and Exalgo (2009 U.S. opioid sales $8.5 billion).

 

Edit g

http://www.redorbit.com/news/health/1882952/theraquest_unveils_new_pain_management_product_pipeline/

allgood
allgood's picture
User offline. Last seen 1 week 4 days ago. Offline
Member
Joined: May 11 2009
Posts: 1252
Sir Ebril
Ivy
User offline. Last seen 3 years 2 weeks ago. Offline
Member
Joined: Feb 18 2010
Posts: 1976
I appreciate it when a person

I appreciate it when a person adds the link along with (their?) information. Thank you for the link allgood Wink

celticgreenman
celticgreenman's picture
User offline. Last seen 3 years 24 weeks ago. Offline
Member
Joined: Nov 10 2010
Posts: 1333
Plagiarism

Agree with allgood and Ivy, even though the origional poster put TheraQuest at the top, if the editorial is not his/her own words, it should be in quotes.

cgm

 

 

HCandKROD
HCandKROD's picture
User offline. Last seen 5 years 23 weeks ago. Offline
Member
Joined: Nov 4 2008
Posts: 427
Interesting

I have been on Levorphanol for years and one of the reasons I like it is after all this time I can feel the physical effects for about 4 hours and the painkilling effects last 7 to 8 hours. My doctor now has been using Levo as my long acting med and Oxycodone as b/t med. I just saw my doc tonight for a 5:45pm appt and he hadn't heard anything about the Levo ER but he would look into it. Also, my pharmacist has commented several times that I am the only person he knows who takes Levo so maybe there is a resurgence of popularity. I would urge anyone who isn't satisfied with their current medication to give Levo a try. It is a very powerful opioid that does work very well on nerve pain because of the way it gets to all three receptors. I think I'll stick to my current rx of 4 to 6 mg tid. I hope everyone has a great day!!!!     Greg

Sir Ebril
User offline. Last seen 4 years 1 week ago. Offline
Member
Joined: Jan 29 2011
Posts: 26
Sorry about that

I wasn't claiming editorial ownership, just passing along some news.

goat
goat's picture
User offline. Last seen 1 week 3 days ago. Offline
Moderator
Joined: Nov 21 2006
Posts: 4985
well

next time cite your sources and all is fine.

SoloCPhT
User offline. Last seen 5 years 48 weeks ago. Offline
Member
Joined: Oct 6 2005
Posts: 2231
I too was kinda surprised to

I too was kinda surprised to read that a company is making an ER formulation of Levo-Dromoran. Since levo itself is a longer acting medication all on its own just like methadone due to its incredibly long half life. I guess its possible they are trying to make it a once daily med, instead of q6-8h like it is now in its immediate release formulation. pot

 Greg, because you speak so highly of levo Ive been wanting to ask my doctor about it for a while now, especially since I liked methadone so well. I think that the added nmda effects really helps with the treatment of CP. My only reservation about asking the doc, is that my doctor is kinda young and will probably have no experience with it at all, heck I was the docs first pt that was ever Rx'd methadone. I still think Im going to mention it, my pharmacist is pretty awesome and can order anything I want overnight so I dont think getting it would be an issue. Another bonus is that the only company that makes it is Roxane and I really think they are a great manufacturer. kettle

 Greg, since you take both levo and oxy ir what would you compare a Levo 2mg tab to in relation to Oxycodone immediate release? I know its not really going to be an equal comparison since levo lasts much longer. Unfortunately Im at the point where no matter what mg tab oxy I take, be it 15, 20 or 30 mg, it only lasts 2-2.5 hours, so I need something that lasts a little longer as a baseline med.

HCandKROD
HCandKROD's picture
User offline. Last seen 5 years 23 weeks ago. Offline
Member
Joined: Nov 4 2008
Posts: 427
Well............

it's kinda tough to compare but if I had to say on the conservative side 4 mg Levo is roughly comparable to 25mg Oxycodone. The effects are not at all like Oxy or Methadone. I like Levo because I am rx'ed 8 mg Xanax a day but the effects of the Levo have a calming effect not to be confused with sedating therefore I rarely take 8mg of Alprazolam. Also, I am rx'ed 30 mg Oxycodone IR QID but I usually take 2and 1/2 to 3 a day and it balances me out because Oxy seems to energize me. I understand your reluctance to ask your doctor. When I changed doc's bout 3 years ago my new doctor had never rx'ed Levo before in his life (he is 56 y/o). I lucked out with my doctor because he is very liberal and listened as I explained the things about Levo that I like and think are benefical including the NMDA effects and the drugs unique action on the 3 receptors in the brain. Indeed, I too am satisfied with Roxane. I have never had a pill or a batch that was "bad". Gee, that's about I can think of right now. I wish you the best of luck and if I can answer any specific questions that you have don't hesitate to post or PM me. Have a great Solo!!!     Greg      Post Script: I couldn't find the website but there is one out there called Levorphanol "The Forgotten Opioid" it has quite a bit of info on it. Plus if you have an account to Springer-Link there is quite a bit of information on there. Tienen una gran noche mis amigos!!! Smile

allgood
allgood's picture
User offline. Last seen 1 week 4 days ago. Offline
Member
Joined: May 11 2009
Posts: 1252
Levorphanol "The Forgotten Opioid"
Sir Ebril
User offline. Last seen 4 years 1 week ago. Offline
Member
Joined: Jan 29 2011
Posts: 26
Levorphanol Tartrate

HCandKROD -

Have you had any availability issues with your Pharmacy?

 

Sir E